Cerevel Therapeutics Holdings, Inc. (CERE)

業務介紹

Cerevel Therapeutics Holdings, Inc.（Cerevel Therapeutics控股有限公司）是一家臨床階段的生物製藥公司，致力於開發各種神經科學疾病的治療方案。該公司正在開發emraclidine，一種正向變構調節劑（PAM），目前正在進行1b期臨床試驗，用於治療精神分裂症；以及Darigabat，一種PAM，目前正在進行2期概念驗證試驗，用於治療藥物耐受性局灶性發作性癲癇或局灶性癲癇患者，同時也正在進行1期試驗以治療急性焦慮症。該公司的產品還包括Tavapadon，一種選擇性多巴胺D1/D5部分激動劑，目前正在進行3期臨床試驗，用於治療早期和晚期帕金森病；CVL-871，一種選擇性多巴胺D1/D5部分激動劑，目前正在進行2a期臨床試驗，用於治療與失智症相關的無動力症；CVL-936，一種選擇性多巴胺D3偏好拮抗劑，目前正在進行I期臨床試驗，用於治療物質濫用障礙；CVL-354，一種選擇性kappa-阿片受體拮抗劑，用於治療重度抑鬱症和物質濫用障礙；以及CVL-047，一種選擇性PDE4抑制劑，用於治療重度抑鬱症和物質濫用障礙。該公司還參與開發一個M4激動劑計劃，用於治療精神病和相關症狀；以及一個LRRK2抑制劑計劃，用於應對帕金森病的疾病進展。該公司成立於2018年，總部位於麻薩諸塞州劍橋市。

Cerevel Therapeutics Holdings, Inc., a clinical-stage biopharmaceutical company, engages in the development of various therapies for neuroscience diseases. It is developing emraclidine, a positive allosteric modulator (PAM) that is in phase 1b clinical trials for the treatment of schizophrenia; and Darigabat, a PAM, which is in Phase 2 proof-of-concept trial in patients with drug-resistant focal onset seizures in epilepsy or focal epilepsy, as well as in phase 1 trial to treat acute anxiety. The company's products also comprise Tavapadon, a selective dopamine D1/D5 partial agonist that is in phase 3 clinical trial for the treatment of early- and late-stage Parkinson's disease; CVL-871, a selective dopamine D1/D5 partial agonist, which is in Phase 2a clinical trial to treat dementia-related apathy; CVL-936, a selective dopamine D3-preferring antagonist, which is in Phase I clinical trial for the treatment of substance use disorder; CVL-354, a selective kappa-opioid receptor antagonist to treat major depressive disorder and substance use disorder; and CVL-047, selective PDE4 inhibitor for the treatment of major depressive disorder and substance use disorder. It is also involved in the development of an M4 agonist program for the treatment of psychosis and related indications; and an LRRK2 inhibitor program to address disease progression in Parkinson's. The company was founded in 2018 and is headquartered in Cambridge, Massachusetts.

公司網址

https://www.cerevel.com